D. Perlin

A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata

This study assesses the fitness costs of drug resistance in C. glabrata isolates across different host environments, showing reduced fitness in macrophages and gut but comparable fitness in the spleen.

Macrophage internalization creates a multidrug-tolerant fungal persister population, providing a permissive reservoir for the emergence of drug resistance

This study shows that macrophage internalization creates drug-tolerant C. glabrata persisters, which can give rise to drug-resistant mutants, and that amphotericin B can kill these persisters.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.