E. Shor

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Quantitative Image Analysis of Tissue Properties: A MATLAB Tool for Measuring Morphology and Co-localization in 2D Images

The paper introduces a MATLAB tool for quantitatively analyzing 2D tissue images, measuring morphology and co-localization parameters with flexibility across different tissue types.

A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata

This study assesses the fitness costs of drug resistance in C. glabrata isolates across different host environments, showing reduced fitness in macrophages and gut but comparable fitness in the spleen.

Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness

This study investigates petite C. glabrata strains, showing they are echinocandin tolerant, induce inflammation, and have poor in vivo fitness, with low global prevalence.

R2R3-MYB EVER links emission of volatiles with epicuticular wax biosynthesis in petunia petal epidermis

This study identifies EVER, a petal-specific MYB activator, linking volatile emission with epicuticular wax biosynthesis in petunia through transcriptomic, genetic, and metabolomic analyses.

Macrophage internalization creates a multidrug-tolerant fungal persister population, providing a permissive reservoir for the emergence of drug resistance

This study shows that macrophage internalization creates drug-tolerant C. glabrata persisters, which can give rise to drug-resistant mutants, and that amphotericin B can kill these persisters.

Multifactorial role of mitochondria in echinocandin tolerance revealed by transcriptome analysis of drug-tolerant cells

This paper identifies a unique transcriptional signature of echinocandin-tolerant Candida glabrata cells and reveals a multifactorial role of mitochondria in drug tolerance.

A non-canonical DNA damage checkpoint response in a major fungal pathogen

This study identifies a non-canonical DNA damage response in Candida glabrata that lacks Rad53 phosphorylation and S-phase arrest, leading to increased lethality and genetic instability.

A mouse bio-electronic nose for sensitive and versatile chemical detection

This paper develops a bio-electronic nose using mouse olfactory signals and machine learning to detect chemicals with sensitivity comparable to trained animals.