Author

J. Schuetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Zubair· 1 shared B. Freeman· 1 shared B. Gordon· 1 shared C. G. Robinson· 1 shared C. R. Grace· 1 shared C. Wright· 1 shared D. Miller· 1 shared E. Stewart· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Zubair

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Author profile →

2 papers

Recent·Most cited

PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link

J. Lynch, Y. Wang, Y. Li, K. Kavidia, Y. Fukuda, S. Ranjit, C. G. Robinson, C. R. Grace, Y. Xia, J. Peng, J. Schuetz

The paper identifies PPIX-binding proteins and shows that increased heme/porphyrin synthesis promotes ferroptosis distinct from canonical ferroptosis, with PRDX3 modulating this process.

bioRxiv · Jun 1, 2022 · PreprintBiochemistry

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

M. Pan, C. Wright, R. Chapple, A. Zubair, M. Sandhu, J. Batchelder, J. Low, K. Blankenship, L. Wang, B. Gordon, P. Archer, S. W. Brady, S. Natarajan, M. Pozsgai, J. Schuetz, , P. Geeleher

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

bioRxiv · Feb 25, 2021Cancer Biology