J. Sengupta

Cryo-EM structures of the Mycobacterium 50S subunit reveal an intrinsic conformational dynamics of 23S rRNA helices

This paper identifies a previously unknown folded conformation of helix 68 in mycobacterial 23S rRNA that contributes to ribosome inactivation during dormancy and suggests it as a therapeutic target.

Transmission of allosteric response within the homotrimer of SARS-CoV-2 spike upon recognition of ACE2 receptor by the receptor-binding domain

This study investigates allosteric communication in the SARS-CoV-2 spike RBD upon ACE2 binding, identifying an allosteric loop as a potential drug target.

Heme minimizes Parkinson’s disease-associated toxicity by inducing a conformational distortion in the oligomers of alpha-Synuclein

This study shows heme reduces alpha-Synuclein toxicity by altering its oligomer structure, preventing harmful fibril formation.

Resveratrol prevents amyloid fibrillation of insulin by arresting it in a bioactive oligomeric form

This study shows resveratrol prevents insulin fibrillation by keeping it in a bioactive oligomeric form and retains its biological activity without toxicity.

Electron microscopy reveals unique spore-like nano forms of Bacillus cereus

The paper uses electron microscopy to identify nano-spore-like structures in Bacillus cereus under stress, showing they can bypass sterile filtration and transform into mature cells upon nutrient supply.