D. Das

Regulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

This study identifies LMAN2 as a regulatory protein that modulates redox-sensitive gating of Kv1.2 channels by altering activation kinetics and redox sensitivity.

Deubiquitinase JOSD1 tempers hepatic proteotoxicity

This study identifies JOSD1 as a deubiquitinase that mitigates hepatic proteotoxicity by stabilizing SOCS1 and enhancing cell survival under proteasome inhibitor stress.

Autoimmunity and clinical pathology amelioration in SLE by Dexamethasone primed Mesenchymal Stem Cell derived conditioned media

This study evaluates dexamethasone-primed mesenchymal stem cell conditioned media for treating SLE, showing improved immunomodulation and organ protection compared to standard therapies.

Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis

The paper identifies HTR2B on MDSCs as a target to enhance immune checkpoint inhibitors in breast-to-brain metastasis using clozapine and anti-PD-1 therapy.

The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence

This study identifies Hog1 MAP kinase as essential for Candida auris skin colonization and intradermal persistence through RNA-seq and phenotypic analyses.

Elucidating ATP's Role as Solubilizer of Biomolecular Aggregate

This study shows ATP prevents protein aggregation and dissolves pre-formed aggregates, suggesting it could be a therapeutic agent for protein-aggregation diseases.

Discovering Novel Prognostic Biomarkers of Hepatocellular Carcinoma using eXplainable Artificial Intelligence

This study uses explainable AI to identify novel genetic biomarkers for HCC prognosis, showing improved accuracy over AFP and highlighting demographic-specific relevance.

Use of multimodal sensory cues in predator avoidance by wild-caught zebrafish shoals

This study examines how wild-caught zebrafish shoals respond to visual, olfactory, and combined predator cues, finding that multimodal cues lead to increased freezing but similar other responses compared to no cues.

Subchronic exposure to ambient PM2.5 impairs novelty recognition and spatial memory

This study shows that subchronic exposure to high PM2.5 levels impairs novelty recognition and spatial memory in mice.

SARS-CoV-2 infection triggers pro-atherogenic inflammatory 1 responses in human coronary vessels

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

BRD4 isoforms have distinct roles in tumor progression and metastasis in embryonal rhabdomyosarcoma

This study shows BRD4-L and BRD4-S isoforms have distinct roles in embryonal rhabdomyosarcoma, with BRD4-L promoting tumor growth and BRD4-S preventing metastasis.

Molecular basis of VEGFR1 autoinhibition at the plasma membrane

This study identifies a mechanism by which VEGFR1 remains constitutively inactive through juxtamembrane inhibition and phosphatase activity, explaining its differential regulation compared to VEGFR2.

Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity

Exact distribution of the quantal content in synaptic transmission

The paper derives the exact distribution of quantal content in synaptic transmission for different AP input patterns and validates it with electrophysiological data from mice.

Effects of microRNA-mediated negative feedback on gene expression noise

This study develops a mathematical model to show how miRNA-mediated negative feedback affects gene expression noise and creates bimodal mRNA distributions near an expression threshold.

Maximization of Energy Recovery from Starch Processing Wastewater by Thermophilic Dark Fermentation Coupled with Microbial fuel Cell Technology

This study maximizes energy recovery from starch wastewater using thermophilic dark fermentation combined with microbial fuel cells, achieving high hydrogen production and COD reduction.

Quantification of differential toxin expressions and their relation to distinct lifespans of bacterial subpopulations associated with diverse host immune mechanisms

This study quantifies differential toxin expression in bacterial subpopulations and links it to their intracellular lifespans and host immune interactions.

Genotypic and phenotypic diversity of the multidrug-resistant Mycobacterium tuberculosis strains from eastern India

This study sequenced Mtb genomes from eastern India to analyze genotypic and phenotypic diversity, revealing high prevalence of MDR lineage-2 strains in NE and lineage-1/3 in Odisha, with local transmission clusters and enrichment of short INDELs in MDR samples.

Modified dN/dS for accounting transition and transversion frequency difference and non-sense substitution in genomes

The paper modifies the dN/dS ratio calculation to account for transition/transversion rate differences and non-sense substitutions, showing higher dN/dS values in E. coli and S. enterica genes.

An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell

This study identifies a thermodynamic brake in ZAP-70 that regulates T cell signaling kinetics and ligand selectivity, with evolutionary implications for immune system divergence.

PHOSPHATE STARVATION RESPONSE enables arbuscular mycorrhiza symbiosis

This study shows that the PHR2 gene regulates arbuscular mycorrhiza symbiosis by controlling phosphate starvation responses in rice, enhancing root colonization and phosphate uptake.

Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins

This study shows that spectrin binding modulates peroxidase activity of hemoglobin and other heme proteins, with implications for oxidative damage in diseases like sickle cell disease.

Exact distribution of threshold-crossing times for protein concentrations: Implication for biological timekeeping

The paper derives the exact distribution of protein concentration threshold-crossing times and applies it to predict lysis times in E. coli holin gene mutants.

Multiple Shoot Regeneration from Excised Embryonic Axis Explants of Jute, Corchorus capsularis cv. JRC321

This study develops an in vitro protocol for multiple shoot regeneration from excised embryonic axis explants of jute, showing successful shoot differentiation and rooting.

Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

This study identifies PI3P and MDR1 as critical for PfAtg18 localization to the food vacuole and suggests a potential role for PfAtg18 in modulating MDR1 activity.

Human papillomavirus 16 E2 repression of TWIST1 transcription is a potential mediator of HPV16 cancer outcomes

This paper shows that HPV16 E2 represses TWIST1 transcription, which may explain the better clinical outcomes in HPV16 positive cancers.

The Protein Hourglass: Exact First Passage Time Distributions for Protein Thresholds

The paper derives an analytical expression for first passage time distributions of protein thresholds, showing agreement with experimental data and analyzing noise properties under different self-regulation conditions.

Characterization of Plasmodium falciparum NEDD8 and identification of cullins as its substrates

This study characterizes Plasmodium falciparum NEDD8 and identifies cullins as its substrates, demonstrating functional conservation of the neddylation pathway in malaria parasites.

Ultra-compact Dual-band Smart NEMS Magnetoelectric Antennas for Simultaneous Wireless Energy Harvesting and Magnetic Field Sensing

This paper introduces an ultra-compact dual-band smart NEMS magnetoelectric antenna for wireless energy harvesting and magnetic field sensing in implantable medical devices.

Comparative metagenomic analysis following treatment with vancomycin in C57BL/6 and BALB/c mice to elucidate host immunity and behavior

This study compares metagenomic changes in Th1 and Th2 biased mice after vancomycin treatment, showing microbiota restoration and associated physiological and behavioral recovery.