S. Bhattacharjee

Mitochondria-derived Vesicles mediate Mito-nuclear Trafficking of Cargo

This study identifies mitochondria-derived vesicles (MDVs) as a novel pathway for transporting mitochondrial proteins to the nucleus in cardiomyocytes.

Global stress response in Pseudomonas aeruginosa upon malonate utilization

This study investigates how Pseudomonas aeruginosa adapts to malonate as a sole carbon source, revealing global gene expression changes and phenotypic responses.

Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling

This study shows that the methionine cycle in serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling pathway in C. elegans.

An arch worth revisiting: A study on the feline humeral supracondylar foramen and its evolutionary significance

This study investigates the feline humeral supracondylar foramen using micro-CT, concluding it is likely a ligamentous or aponeurotic structure rather than a homologous counterpart to the human supracondyloid foramen.

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

Variability in HIV-1 Transmitted/Founder Virus Susceptibility to Combined APOBEC3F and APOBEC3G Host Restriction

This study investigates how APOBEC3F and APOBEC3G interact to resist HIV-1 Vif-mediated degradation and shows subtype-specific differences in Vif activity against these enzymes.

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

RNA Binding of Syntaxin 5 Synergises Membrane Fusion to Accelerate miRNA Export and Clear Pathogens

This paper identifies Syntaxin5's role in miRNA export and pathogen clearance by showing its RNA-binding and SNARE domain functions in macrophages.

Structural insight into translation initiation of the ????cl leaderless mRNA

This study uses cryo-EM to reveal structural insights into the translation initiation of leaderless mRNA by examining the uS2-deficient ribosome and its interaction with the lambda cI lmRNA.

Beyond Traditional Methods: Innovative Integration of LISS IV and Sentinel 2A Imagery for Unparalleled Insight into Himalayan Ibex Habitat Suitability

This study integrates LISS IV and Sentinel 2A satellite data with machine learning to improve habitat suitability mapping for Himalayan Ibex, achieving high classification accuracy and identifying key environmental factors.

Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling

This paper introduces a microfluidic chip for time-resolved cryo-EM to study HflX-mediated ribosome recycling, capturing reaction intermediates at high resolution.

Overexpression of Interleukin-8 and Interleukin-13 as potent immune markers associated with survival and dietary habits in esophageal squamous cell carcinoma.

The paper evaluates the expression of IL8, IL12, and IL13 in ESCC patients and links their levels to survival, clinicopathological factors, and dietary habits.

Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-beta Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis

This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.

Leishmania Hijacks microRNA Import-Export Machinery of Infected Macrophage and Survives by Cross-Communicating Host miR-146a to Subjugate HuR and miR-122 in Neighbouring cells

This study shows Leishmania manipulates host miRNA transport to suppress inflammation and promote its survival by exporting miR-146a and inhibiting miR-122 in neighboring cells.

A conserved Guided Entry of Tail-anchored pathway is involved in the trafficking of tail-anchored membrane proteins in Plasmodium falciparum.

This study identifies the conserved GET pathway components in Plasmodium falciparum and their association with predicted TA proteins, validating the pathway's functional existence in the parasite.

Plasmodium falciparum Kelch13 and its artemisinin-resistant mutants assemble as hexamers in solution: a SAXS data driven shape restoration study.

This study uses SAXS data to show that PfKelch13 forms a stable hexamer with specific domain arrangements, and that resistant mutants have altered spatial configurations.

Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalks between SA-dependent immunity and phosphate-starvation responses

This study shows that Arabidopsis IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses by affecting SA levels and PSI-gene expression.

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

Arabidopsis inositol polyphosphate kinases regulate COP9 signalosome deneddylase functions in phosphate-homeostasis

This study shows Arabidopsis InsP-kinases IPK1 and ITPK1 regulate CSN-CRL dynamics, affecting phosphate homeostasis and stress responses through deneddylation of cullins.

Transmission of allosteric response within the homotrimer of SARS-CoV-2 spike upon recognition of ACE2 receptor by the receptor-binding domain

This study investigates allosteric communication in the SARS-CoV-2 spike RBD upon ACE2 binding, identifying an allosteric loop as a potential drug target.

Proteomic analysis of SUMO1-SUMOylome changes during defense elicitation in Arabidopsis

The paper identifies SUMO1-substrates in Arabidopsis during defense responses, showing increased SUMOylation and diverse roles in immune and cellular processes.

Contrasting functions of Arabidopsis SUMO1/2 isoforms with SUMO3 intersect to modulate innate immunity and global SUMOylome responses

This study investigates the functional interactions between SUMO1/2 and SUMO3 isoforms in Arabidopsis, revealing their roles in modulating innate immunity and global SUMOylome responses to biotic and abiotic stresses.

ITPK1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis thaliana

This study shows that ITPK1 produces 5-InsP7, which binds to auxin receptors and influences plant growth responses.

Proteasomal Inhibition Triggers Viral Oncoprotein Degradation via Autophagy-Lysosomal Pathway

This study shows proteasomal inhibition causes degradation of EBNA3A and EBNA3C viral oncoproteins via autophagy-lysosomal pathway, while EBNA3B remains stable, suggesting potential therapeutic use of proteasome inhibitors for EBV-related B-cell lymphomas.