J. W. Smith

Molecular architecture and platelet-activating properties of small immune complexes assembled on intact heparin and their possible involvement in heparin-induced thrombocytopenia

This study characterizes small immune complexes formed by PF4, heparin, and HIT antibodies using native mass spectrometry, revealing their structure and platelet-activating properties.

Electron Videography of a Lipid-Protein Tango

This study uses liquid-phase transmission electron microscopy to image nanoscale lipid-protein interactions in unlabelled membrane protein nanodiscs, revealing long-range lipid effects on nanodisc stability.

Vascular proteome responses precede organ dysfunction in sepsis

This study identifies vascular proteome changes preceding organ dysfunction in sepsis using a murine model and integrative analysis.

Quantitative profiling of protease specificity.

The paper develops a method to quantitatively profile protease specificity using selectome analysis, substrate phage display, and next-generation sequencing to distinguish between closely related proteases.