S. Freeman

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

This study identifies genomic heterogeneity and ploidy as markers of intrinsic resistance to PD-1 blockade in metastatic melanoma, with a decision tree model predicting resistance with high confidence.

Nationally endorsed learning objectives to improve course design in introductory biology

This paper develops nationally endorsed learning objectives for introductory biology courses to improve course design and student success through alignment with assessments and active learning.

Evaluating goodness-of-fit of animal movement models using lineups

The paper evaluates goodness-of-fit for animal movement models using the lineup protocol, demonstrating its application to fisher data with integrated step-selection and hidden Markov models.

Modeling individual variability in habitat selection and movement using integrated step-selection analyses

The paper develops methods to model individual variability in habitat selection and movement using integrated step-selection analyses with random effects, applied to red snapper data.

Computational investigation of mechanisms for pH modulation of human chloride channels

This paper introduces a computational method to identify pH-sensitive amino acids in chloride channels by calculating pKas, validated across multiple proteins and applied to predict pH modulation in ion channel disorders.

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

From the Modern Synthesis to the Molecular Synthesis: updating how we teach and assess evolution by natural selection

This paper proposes reorganizing introductory biology courses to focus on the Molecular Synthesis, developing assessment tools to evaluate students' understanding of genotype-phenotype-fitness connections in evolution.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

This study identifies FGFR and FGF pathway alterations as acquired resistance mechanisms to ER-targeted therapy in ER+ metastatic breast cancer and suggests targeted inhibitors as potential treatments.