Cell BiologybioRxiv
Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis
G. Contento, J.-A. A. Wilson, B. Selvarajah…·R. C. Chambers
This study shows that pyruvate metabolism affects fibroblast response to GLS1 inhibition during fibrosis, suggesting combined targeting of pyruvate metabolism and glutaminolysis as a therapeutic strategy.
DOI 10.1172/jci.insight.178453