Author

M. Plate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Guillotin· 2 shared R. Chambers· 2 shared A. Alhendi· 1 shared A. Blanchard· 1 shared A. Dos Santos Dias· 1 shared A. Fisher· 1 shared A. Khabbush· 1 shared A. Taylor· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

D. Guillotin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

R. Babaei-Jadidi, D. Clements, Y. Wu, K. Chen, S. Miller, M. Plate, K. Lim, R. Chambers, E. L. Rawlins, Y. Xu, S. R. Johnson

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

bioRxiv · May 3, 2024 · PreprintCell Biology

Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities

S. Loukogeorgakis, F. Michielin, S. Shibuya, N. Al-Juffali, J. Jimenez, J. Allen-Hyttinen, P. Eastwood, A. Alhendi, J. Davidson, E. Naldi, P. Maghsoudlou, A. Tedeschi, S. Khalaf, A. Khabbush, M. Plate, , P. De Coppi

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

bioRxiv · Feb 20, 2024Bioengineering

Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis

G. Contento, J.-A. A. Wilson, B. Selvarajah, M. Plate, D. Guillotin, V. Morales, M. Trevisani, V. Pitozzi, K. Bianchi, R. C. Chambers

This study shows that pyruvate metabolism affects fibroblast response to GLS1 inhibition during fibrosis, suggesting combined targeting of pyruvate metabolism and glutaminolysis as a therapeutic strategy.

bioRxiv · Jan 30, 2024Cell Biology

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

D. Guillotin, A. Taylor, M. Plate, P. Mercer, L. Edwards, R. Haggart, G. Miele, R. McAnulty, T. Maher, R. E. Hynds, M. Jamal-Hanjani, R. Marshall, A. Fisher, A. Blanchard, R. Chambers

This study identifies key transcriptional pathways in IPF fibroblastic foci using RNA-seq and bioinformatics, highlighting the TSC2/RHEB axis as a potential therapeutic target for fibrosis.

bioRxiv · Mar 10, 2020Cell Biology