Anjali P. Kusumbe

This paper describes a standardized protocol for creating mouse models of bisphosphonate-related and radiation-induced jaw osteonecrosis using minimally invasive surgical and irradiation techniques.

This study identifies vascular and lymphatic dysfunction in BRONJ, revealing the COL2A1-CD44/SDC4 axis as a therapeutic target through multimodal analysis of mouse and human samples.

The paper identifies bone lymphatic endothelial cells as a distinct population that drives skeletal repair and shows that their dysfunction contributes to mandibular diseases.

The paper redefines skeletal endothelial heterogeneity by showing the proposed type R population is part of a venous continuum and includes fatty acid-handling endothelial cells.

This paper introduces a protocol for rapid, high-resolution 3D imaging of intact calcified tissues using immunostaining and light-sheet microscopy.

The paper develops a Wnt-induced osteogenic tissue model (WIOTM) that sustains H3K14-acetylation in human skeletal stem cells, promoting bone repair through asymmetric cell division.

The paper shows that skull bone marrow is vulnerable to age-related decline, contradicting previous claims of resilience, and highlights its role in blood and immune health.

This study identifies an endogenous NCAM1-14.3.3.ζδ-derived peptide interaction that promotes angiogenesis and osteogenesis, offering a therapeutic target for age-related bone diseases.