ImmunologyMolecular NeurodegenerationPeer-reviewed
ASO-mediated knockdown of GPNMB in mutant-GRN and Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses
Rebecca L. Wallings, Drew A. Gillett, Hannah A. Staley…·Malú G. Tansey
This study shows that reducing GPNMB in progranulin-deficient myeloid cells impairs lysosomal function and immune responses, suggesting GPNMB is essential for maintaining immune homeostasis.
8 citations