Malú G. Tansey

This review synthesizes findings on peripheral immune cell changes in Parkinson's disease, identifying common immune signatures and methodological inconsistencies across studies.

This study investigates how RGS10 modulates NFκB subunit transcription and inflammatory cytokine profiles in peritoneal macrophages through experimental stimulation and transcript analysis.

The paper uses single-cell multiomics to identify shared and unique immune dysfunction features in Parkinson's disease and inflammatory bowel disease across gut, plasma, and stool samples.

The paper stratifies Parkinson's disease stages based on peripheral immune cell responses to stimulation, identifying biomarkers linked to disease progression.

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

This study shows that reducing GPNMB in progranulin-deficient myeloid cells impairs lysosomal function and immune responses, suggesting GPNMB is essential for maintaining immune homeostasis.

The paper compares gut microbiomes of Parkinson's disease and inflammatory bowel disease patients, finding shared depletions in butyrate-producing bacteria across multiple datasets.

The paper identifies cell type-specific molecular changes in the prefrontal cortex of C9orf72 ALS/FTD patients correlated with pTDP-43 levels.

The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.

This study shows that systemic XPro1595, a TNF inhibitor, does not protect against -Syn-induced Parkinson's-like pathology in rats, despite being effective in other neurodegeneration models.

The paper investigates shared iron storage and transport deficits in PBMCs from PD and IBD patients, linking them to immune dysfunction and NSAID modulation.

This study shows that systemic administration of a TNF inhibitor does not protect against α-synuclein-induced dopaminergic neuron loss in a rat model of Parkinson's disease.

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

This study shows that the Alzheimer's protective PLCG2-P522R variant affects peripheral macrophage function differently in males and females.

This study investigates GPNMB upregulation and MITF dysregulation in progranulin-deficient macrophages, linking them to early-stage neurodegenerative disease mechanisms.

This study uses spatial proteomics to identify subregion-dependent protein changes in dementia variants, revealing disease-specific patterns in cortical layers and white matter.

The paper shows that a high-fat, high-carbohydrate diet causes sex-specific metabolic and inflammatory issues in 5xFAD mice, which are partially reversed by inhibiting soluble TNF in males.

The paper develops a protocol to assess human α-Synuclein solubility in Drosophila brains, distinguishing soluble and insoluble forms using detergent strength and sonication.

This study shows that LC injury modifies neuroinflammation in the ventral midbrain during DSS-induced colitis, highlighting the neuroprotective role of the locus coeruleus.

This study examines the gut-brain axis in a mouse colitis model, identifying immune activation, oxidative stress, and myelination disruptions in the brain linked to intestinal permeability.

This study shows that C1q-dependent engulfment of alpha-synuclein by ENS macrophages leads to their exhaustion and worsens Parkinson's-like gut pathology.

The paper evaluates cell isolation methods for mouse brain immune profiling and uses PIPseq to study microglia-peripheral immune crosstalk during LPS-induced neuroinflammation.

This study evaluates intrathecal riluzole delivery in dogs to achieve spinal cord concentrations comparable to oral dosing without systemic side effects or elevated brain concentrations.

This study shows that reducing mutant Lrrk2 in macrophages decreases lysosomal tubule formation and pro-inflammatory responses, suggesting potential therapeutic benefits for LRRK2-related Parkinson's but possible immune system side effects.

The paper develops a sensitive Bio-ELISA to measure TH in immune cells and finds that TNFα increases TH expression in monocytes from Parkinson's patients.

This study develops a transgenic mouse model expressing human alpha-synuclein in noradrenergic neurons, revealing LC pathology and non-motor PD features.

This study investigates sex differences in inflammatory responses and gut microbiota in a progressive monkey model of Parkinson's disease following MPTP treatment.