Hannah A. Staley

The paper investigates how an influenza A-derived immune engram influences anxiety and cytokine expression through CGRP signaling in the posterior insula.

The paper uses single-cell multiomics to identify shared and unique immune dysfunction features in Parkinson's disease and inflammatory bowel disease across gut, plasma, and stool samples.

The paper stratifies Parkinson's disease stages based on peripheral immune cell responses to stimulation, identifying biomarkers linked to disease progression.

This study shows that reducing GPNMB in progranulin-deficient myeloid cells impairs lysosomal function and immune responses, suggesting GPNMB is essential for maintaining immune homeostasis.

The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.

This study shows that systemic XPro1595, a TNF inhibitor, does not protect against -Syn-induced Parkinson's-like pathology in rats, despite being effective in other neurodegeneration models.

The paper investigates shared iron storage and transport deficits in PBMCs from PD and IBD patients, linking them to immune dysfunction and NSAID modulation.

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

This study shows that the Alzheimer's protective PLCG2-P522R variant affects peripheral macrophage function differently in males and females.

This study shows that targeting CB2 with SMM-189 reduces alpha-synuclein aggregates and neuroinflammation in a rat model of Parkinson's disease.

This study shows that reducing mutant Lrrk2 in macrophages decreases lysosomal tubule formation and pro-inflammatory responses, suggesting potential therapeutic benefits for LRRK2-related Parkinson's but possible immune system side effects.