Rebecca L. Wallings

The paper stratifies Parkinson's disease stages based on peripheral immune cell responses to stimulation, identifying biomarkers linked to disease progression.

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

This study shows that reducing GPNMB in progranulin-deficient myeloid cells impairs lysosomal function and immune responses, suggesting GPNMB is essential for maintaining immune homeostasis.

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

This study shows that the Alzheimer's protective PLCG2-P522R variant affects peripheral macrophage function differently in males and females.

This study investigates GPNMB upregulation and MITF dysregulation in progranulin-deficient macrophages, linking them to early-stage neurodegenerative disease mechanisms.

This study shows that reducing mutant Lrrk2 in macrophages decreases lysosomal tubule formation and pro-inflammatory responses, suggesting potential therapeutic benefits for LRRK2-related Parkinson's but possible immune system side effects.