ImmunologybioRxivPreprint
Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control
Brian P. Riesenberg, Evelyn J. Gandy, Andrew S. Kennedy…·Jessica E. Thaxton
This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.