Glioblastoma model mouse rescue from mortality by brain-targeted catalytically-enhanced angiotensin-converting enzyme 2 mutant-antibody fusion protein
Pete Heinzelman, George R Nageeb, John Choi…·Michael Lim
The paper shows that combining ACE2dm-s1 with a STING agonist improves survival in GBM model mice, unlike losartan alone, and suggests ACE2dm-s1 modulates the tumor microenvironment.