Synthesis and validation of click-modified of NOD1/2 agonists
R. Bharadwaj, M. V. Anonick, S. Mashayekh…·C. L. Grimes
This study synthesizes and validates click-modified muropeptides as tools to study NOD1/2 innate immune sensing mechanisms.
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3 papers
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R. Bharadwaj, M. V. Anonick, S. Mashayekh…·C. L. Grimes
This study synthesizes and validates click-modified muropeptides as tools to study NOD1/2 innate immune sensing mechanisms.
K. A. Wodzanowski, A. M. Kloxin, C. L. Grimes
This paper introduces a 3D culture system to study macrophage response to bacteria, showing cytokine release and in situ peptidoglycan labeling.
K. L. Bersch, K. E. DeMeester, R. Zagani…·C. L. Grimes
This study synthesizes PG-based disaccharide ligands and screens them against BMDMs to reveal distinct gene induction patterns compared to monosaccharides, showing complex innate immune signaling.