KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity
S. Lu, H. S. Kim, Y. Cao, K. Bedi, K. Chain, L. Zhao, I. V. Narayanan, Z. Yi, J. Yang, Y. Gu, M. T. Paulsen, M. Ljungman, S. Jeyarajan, D. Thomas, Y. Dou, , J. Shi
This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.
bioRxiv · Apr 2, 2020Cancer Biology