Z. Yi

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration

This paper presents a 3D-printed composite scaffold system for bone regeneration that accelerates ECM and mineralized osteoid deposition in vivo.

TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells

This study shows that TLR9 activation in wounds promotes tissue repair and hair follicle regeneration through gamma delta T cells by increasing AREG production and modulating keratinocyte fate.

Rbbp8nl contributes to resistance to anticancer immunotherapy by creating a non-inflamed tumor microenvironment and attenuating CD8+ T cell infiltration

This study identifies RBBP8NL as a factor that reduces immune response in tumors by creating a non-inflammatory microenvironment and limiting CD8+ T cell infiltration, suggesting it as a target for improving immunotherapy.

Monocytes reprogrammed by 4-PBA potently contribute to the resolution of inflammation and atherosclerosis

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

Magnetic nanocomplexes coupled with an external magnetic field modulate macrophage phenotype: a non-invasive strategy for bone regeneration.

This study uses magnetic nanocomplexes with an external magnetic field to shift macrophage phenotype from proinflammatory to prohealing, promoting bone regeneration by modulating inflammation.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

Spp1 secreted by macrophages impairs osteogenic ability of Ctsk+Fmod+ periosteal cells in jaw bone

The paper identifies a Ctsk+Fmod+ periosteal cell subset in jaw bones that is impaired by Spp1 secreted by macrophages, highlighting a potential target for improving bone grafting.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

The Piks allele of the NLR immune receptor Pik breaks the recognition of AvrPik effectors of the rice blast fungus

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

A novel inovirus reprograms metabolism and motility of marine Alteromonas

This study isolates and characterizes a novel inovirus, {phi}AFP1, from Alteromonas abrolhosensis, revealing its impact on host metabolism and motility through transcriptomic analysis.

Rotations improve the diversity of rhizosphere soil bacterial communities, enzyme activities and tomato yield

This study shows that rotating tomato with eggplant or arrowhead improves rhizosphere bacterial diversity, enzyme activity, and tomato yield and quality while reducing nitrate content.

The sowing date changed the temperature and light conditions in the field modified the cadmium content of brown rice (Oryza sativa L.) by regulating the expression of Cd-related genes

This study shows that sowing date affects temperature and light conditions during rice growth, which in turn modifies cadmium content in brown rice by regulating Cd-related gene expression.

Exosomal miR-106b-5p promotes Mtb survival via targeting CREB5 followed by SOAT1-CIDEC and CASP9-CASP3 pathway

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

A free-living protist that lacks canonical eukaryotic DNA replication and segregation systems

This study identifies a free-living protist, Carpediemonas membranifera, that lacks canonical eukaryotic DNA replication and segregation systems, suggesting novel mechanisms for these processes.

Establishment of a closed artificial ecosystem to ensure human long-term survival on the moon

This study describes a 370-day closed artificial ecosystem experiment to test bioregenerative life support systems for long-term lunar habitation, demonstrating high material closure and system stability.

A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2

The paper develops a BAC-vectored SARS-CoV-2 replicon for antiviral screening and virus-host interaction studies, showing sensitivity to IFN-, remdesivir, and ZAP overexpression.

Multi-site co-mutations and 5'UTR CpG immunity escape drive the evolution of SARS-CoV-2

The paper identifies four dominant mutations, three significant multi-site co-mutations, and a 5'UTR CpG escape mutation that drive the rapid evolution of SARS-CoV-2.

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

Hepatitis C virus NS5A inhibitor daclatasvir allosterically impairs NS4B-involved protein-protein interactions within the viral replicase and disrupts the replicase quaternary structure in a replicase assembly surrogate system

This study investigates how daclatasvir impairs HCV replicase assembly by disrupting NS4B-involved protein interactions and altering replicase quaternary structure.

Aging Of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations And Lymphoid Tissue Homing

This study shows that aging of antiviral CD8+ memory T cells leads to increased survival, metabolic adaptations, and lymphoid tissue homing, enhancing their recall response capabilities.