Author

K. Chester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

B. Draper· 2 shared J. Anderson· 2 shared M. Barisa· 2 shared A. C. Rios· 1 shared A. Chakravarthy· 1 shared A. Feber· 1 shared A. Greppi· 1 shared A. Kanouta· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioengineering

B. Draper

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

M. Barisa, E. Zappa, H. Muller, R. Shah, J. Buhl, B. Draper, C. Himsworth, C. Bowers, S. Munnings-Tomes, M. Nicolaidou, S. Morlando, K. Birley, C. Leboreiro-Babe, A. Vitali, L. Privitera, , J. Anderson

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

bioRxiv · Feb 19, 2024Bioengineering

OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity

D. Fowler, M. Barisa, A. Southern Navarrete, C. Nattress, E. Hawkins, E. Vassalou, A. Kanouta, J. Counsell, E. M. Rota, P. Vlckova, B. Draper, C. J. Tape, K. Chester, J. Anderson, J. Fisher

OPS-γδ cells, engineered to secrete opsonins and stabilized IL15, show enhanced cytotoxicity and bystander activation for solid tumor control.

bioRxiv · Oct 23, 2022 · PreprintImmunology

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

A. Chakravarthy, I. Reddin, S. Henderson, C. Dong, N. Kirkwood, M. Jeyakumar, D. Rothschild Rodriguez, N. Gonzalez Martinez, J. McDermott, X. Su, N. Egawa, C. S. Fjeldbo, V. E. Skingen, M. K. Halle, C. Krakstad, , T. R. Fenton

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

bioRxiv · Apr 2, 2020 · PreprintCancer Biology