Cell BiologybioRxiv
Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules
A. PARCHURE, M. Tian, C. K. Boyer…·J. von Blume
The paper shows that chromogranin proteins undergo liquid-liquid phase separation at the TGN to recruit and sort proinsulin and other cargo molecules into secretory granules, independent of specific sequence elements.
DOI 10.1083/jcb.202206132