Nutrient metabolism regulates insulin granule formation in the pancreatic islet β-cell via ER redox homeostasis
K. E. Rohli, C. K. Boyer, S. C. Bearrows, M. R. Moyer, W. S. Elison, C. J. Bauchle, S. E. Blom, C.-L. Yu, M. R. Pope, J. Zhang, Y. Wang, S. B. Stephens
This study shows that nutrient metabolism and ER redox homeostasis regulate insulin granule formation in pancreatic β-cells, linking glucose metabolism to proinsulin export and T2D pathogenesis.
bioRxiv · Sep 22, 2021 · PreprintCell Biology