K. Godula

Human extracellular sulfatases use a dual mechanism for regulation of growth factor interactions with heparan sulfate proteoglycans

This study identifies a dual mechanism by which sulfatases modulate growth factor interactions with heparan sulfate proteoglycans using chemically defined substrates.

Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.

Biologically-derived neoproteoglycans for profiling protein-glycosaminoglycan interactions

This paper introduces neoproteoglycans (neoPGs) as biologically-derived probes to study protein-glycosaminoglycan interactions, enabling real-time monitoring and analysis of ligand binding and enzyme specificity.

Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments

The paper introduces a stem cell microarray platform to assess how glycosaminoglycans influence growth factor signaling in engineered microenvironments.

Glycocalyx crowding with synthetic mucin mimetics strengthens interactions between soluble and virus-associated lectins and cell surface glycan receptors

The paper uses synthetic mucin mimetics to model the glycocalyx and shows that increasing its density enhances lectin and virus retention on cell surfaces.

Mucin-mimetic glycan arrays integrating machine learning for analyzing receptor pattern recognition by influenza A viruses

This study uses a glycan array platform with machine learning to analyze how influenza A virus binding preferences change with receptor presentation and viral propagation conditions.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.