E. Sanchez

Rewiring of the host cell metabolome and lipidome during lytic gammaherpesvirus infection is essential for infectious virus production

This study identifies metabolic rewiring in host cells during gammaherpesvirus infection, showing that glucose, glutamine, and lipid metabolism are essential for viral production.

A linear DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain elicits protective immunity in domestic cats

This study evaluates a linear DNA vaccine in domestic cats, showing it is safe and induces immune responses against SARS-CoV-2.

Alkaloid avoidance in poison frog tadpoles

This study examines how poison frog tadpoles respond to alkaloid exposure, finding they survive with mild developmental effects and learn to avoid toxins over time.

Mechanically active integrins direct cytotoxic secretion at the immune synapse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

Mucin-mimetic glycan arrays integrating machine learning for analyzing receptor pattern recognition by influenza A viruses

This study uses a glycan array platform with machine learning to analyze how influenza A virus binding preferences change with receptor presentation and viral propagation conditions.

Metagenome-assembled genomes from Monte Cristo Cave (Diamantina, Brazil) reveal prokaryotic lineages as functional models for life on Mars

This study reconstructs genomes from a Brazilian cave to explore prokaryotic lineages with potential relevance to life on Mars.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.

Actin clearance promotes polarized dynein accumulation at the immunological synapse

This study shows that actin clearance is required for dynein accumulation at the immunological synapse, which drives centrosome reorientation in T cells.

Control of Mast Cell Regulated Exocytosis by Munc13 Proteins

This study identifies Munc13-4 as essential for mast cell regulated exocytosis and IgE-mediated anaphylaxis, while Munc13-2 plays a minor role.