Author

K. Irie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Y. Fujiyoshi· 3 shared H. Nakanishi· 2 shared K. Abe· 2 shared Y. Suda· 2 shared A. Kita· 1 shared A. Nakano· 1 shared A. Saito· 1 shared G. L. Rudow· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiochemistry

Y. Fujiyoshi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Remodeling of the secretory pathway is coordinated with de novo membrane formation in budding yeast gametogenesis

Y. Suda, H. Tachikawa, T. Suda, K. Kurokawa, A. Nakano, K. Irie

The paper shows that ERES regeneration in budding yeast spores facilitates PSM growth by promoting Golgi reassembly after a transient stall in membrane traffic.

bioRxiv · Jul 10, 2023Cell Biology

Automation of yeast spot assays using an affordable liquid handling robot

S. Taguchi, Y. Suda, K. Irie, H. Ozaki

This study automates yeast spot assays using an affordable liquid-handling robot and flatbed scanner, enabling reproducible and customizable experiments in conventional labs.

bioRxiv · Jul 16, 2022Bioengineering

APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex

A. Saito, Y. Kageyama, O. Pletnikova, G. L. Rudow, Y. An, Y. Irie, A. Kita, K. Miki, L. Li, P. Southall, K. Irie, J. C. Troncoso

This study shows that the APOE ε4 allele causes earlier age-related decline in amyloid β clearance in the human cortex, supporting early intervention strategies for Alzheimer's disease.

bioRxiv · Apr 7, 2021 · PreprintPathology

Crystal structure of a human plasma membrane phospholipid flippase

H. Nakanishi, K. Irie, K. Segawa, K. Hasegawa, Y. Fujiyoshi, S. Nagata, K. Abe

The paper determines the crystal structure of the ATP11C-CDC50A complex and proposes a model for phosphatidylserine translocation across the plasma membrane.

bioRxiv · Dec 23, 2019Biochemistry

A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence

T. Shimomura, Y. Yonekawa, H. Nagura, M. Tateyama, Y. Fujiyoshi, K. Irie

The paper identifies a native prokaryotic Cav channel, CavMr, and shows that a glycine residue in its selectivity filter determines Ca2+ selectivity, conserved in eukaryotic Cavs.

bioRxiv · Oct 17, 2019Biophysics

A single K+-binding site in the crystal structure of the gastric proton pump

K. Yamamoto, V. Dubey, K. Irie, H. Nakanishi, H. Khandelia, Y. Fujiyoshi, K. Abe

The paper determines the crystal structure of the gastric proton pump, revealing a single K+-binding site and confirming a 1H+/1K+ exchange per ATP hydrolysis.

bioRxiv · Apr 15, 2019Biochemistry