S. Nagata

Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo

This study identifies an antibody, CV804, that targets the conserved S2 domain of coronaviruses and shows broad cross-reactivity and ADCC activity against SARS-CoV-2 and related viruses.

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection

This study develops a biparatopic anti-TNFR2 antagonist that binds in a 1:1 ratio, preventing unwanted signal transduction and suppressing regulatory T cell proliferation.

Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

Distinct Expansion of Group II Introns Depends on the Type of Intron-encoded Protein and Genomic Signatures in Prokaryotes

The paper systematically analyzes group II introns in prokaryotes, finding differences in their expansion based on intron-encoded protein types and genomic signatures.

An intramolecular scrambling path controlled by a gatekeeper in Xkr8 phospholipid scramblase

The paper determines the structure of Xkr8-Basigin phospholipid scramblase at 3.8 Å resolution, revealing a gatekeeper tryptophan residue essential for phospholipid scrambling.

Human iPSC-derived hypertrophic chondrocytes reveal a mutation-specific unfolded protein response in chondrodysplasias

The paper evaluates mutation-specific unfolded protein response in chondrodysplasias using human iPSC-derived hypertrophic chondrocytes and identifies differential ER stress and gene expression changes.

Crystal structure of a human plasma membrane phospholipid flippase

The paper determines the crystal structure of the ATP11C-CDC50A complex and proposes a model for phosphatidylserine translocation across the plasma membrane.

The two-step chemosensory system underlying the oligophagy of silkworm larvae

This study identifies a two-step chemosensory system in silkworm larvae that integrates plant chemical cues to determine host acceptance.