A. Saito

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

Generation of a porcine cell line stably expressing pig TMPRSS2 for efficient isolation of viruses from pigs with respiratory diseases

Transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant

This study investigates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant, finding it to be highly immune evasive but with lower infectivity compared to other variants.

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

Generation of porcine PK-15 cells lacking the Ifnar1 gene to optimize the efficiency of viral isolation

This study generates a PK-15 cell line lacking the Ifnar1 gene to improve viral isolation efficiency from contaminated clinical samples.

Host ZCCHC3 blocks HIV-1 infection and production by a dual mechanism

This study identifies ZCCHC3 as a novel anti-HIV-1 factor that acts through a dual mechanism to block viral infection and production.

Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style

The paper shows marmoset infants adjust their attachment behaviors based on caregivers' parenting styles, mirroring human attachment dynamics.

Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus

This study identifies NTCP as the entry receptor for domestic cat hepadnavirus, showing similarity to HBV and suggesting potential for cross-species transmission.

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

This study demonstrates that 2-bromopropane induces lung tumors and testicular toxicity in rasH2 mice after 26 weeks of inhalation exposure.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2

This study investigates how cetylpyridinium chloride (CPC) inactivates SARS-CoV-2 by inhibiting the interaction between the viral spike protein and ACE2 receptor.

Identification of domestic cat hepadnavirus from a cat blood sample in Japan

The study identifies a domestic cat hepadnavirus infection in a Japanese cat, showing genetic differences from global strains.

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.

This study develops a stable SARS-CoV-2 replicon system for high-throughput antiviral screening under BSL2 conditions, demonstrating its utility with remdesivir and interferon-β.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance

The paper investigates the SARS-CoV-2 Lambda variant, finding it more infectious due to specific mutations and better immune evasion, contributing to its spread in South America.

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

Rapid inactivation of SARS-CoV-2 variants by continuous and intermittent irradiation with a deep-ultraviolet light-emitting diode (DUV-LED) device

This study evaluates the antiviral efficacy of DUV-LED irradiation against SARS-CoV-2 variants, finding rapid inactivation with both continuous and pulsed irradiation.

APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex

This study shows that the APOE ε4 allele causes earlier age-related decline in amyloid β clearance in the human cortex, supporting early intervention strategies for Alzheimer's disease.

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

Rapid inactivation of SARS-CoV-2 with ozone water

This study evaluates how ozone water inactivates SARS-CoV-2 based on concentration and exposure time, finding high effectiveness at 10 mg/L within 5 seconds.

Rapid inactivation of SARS-CoV-2 with Deep-UV LED irradiation

This study shows that deep-UV LED irradiation rapidly inactivates SARS-CoV-2 in vitro, suggesting potential for air and surface disinfection.

Generation of human bronchial organoids for SARS-CoV-2 research

This paper generates human bronchial organoids that support SARS-CoV-2 infection and drug testing, showing reduced viral load with TMPRSS2 inhibition.

Stage-Dependent Differential Gene Expression Profiles of Cranial Neural Crest Cells Derived from Mouse Induced Pluripotent Stem Cells

This study identifies stage-dependent gene expression profiles of cNCCs derived from mouse iPSCs, highlighting distinct molecular markers and potential roles in migration.