C. Meng

Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase

This study shows that butyrate is metabolized into the TCA cycle in fly heads and increases oxygen consumption without affecting proteome or acetylome.

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life: a randomized controlled interventional trial with infant formula

This study shows that microbiota and metabolite rhythmicity develops early in life, influenced by diet and breastfeeding, with GOS-supplemented formula promoting bifidobacteria.

Untargeted metabolomics reveals PTI-associated metabolites in cultivated tomato

The paper uses untargeted metabolomics to identify PTI-associated metabolites in tomato plants responding to fungal elicitors and pathogens.

Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in Arabidopsis

This study shows that phosphorylation of the TRAPPII complex by AtSKs regulates adaptive growth responses in Arabidopsis under stress conditions.

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

This study shows that altering meal timing (restricted feeding) can restore intestinal clock function and reduce inflammation in IBD models.

Nutritional and host environments determine community ecology and keystone species in a synthetic gut bacterial community

The paper identifies keystone species in a synthetic gut bacterial community and shows their roles vary with nutritional and host environments.

Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan

The paper demonstrates that increasing mitochondrial membrane potential in C. elegans using a light-activated proton pump extends lifespan and reverses age-related phenotypes.

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

Exploring the interaction network of a synthetic gut bacterial community

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.

Comparative Analysis of Genetically-Modified Crops: Conditional Equivalence Criteria

This paper proposes a conditional equivalence criterion for assessing genetically-modified crops, showing it provides more robust equivalence assessment than the EFSA criterion, especially for traits with negligible unintended effects.

Biophysical and proteomic analyses suggest functions of Pseudomonas syringae pv tomato DC3000 extracellular vesicles in bacterial growth during plant infection

This study identifies proteins in extracellular vesicles of Pseudomonas syringae pv. tomato DC3000 and suggests their roles in bacterial growth and plant infection.

Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic

The paper identifies and characterizes ORF3d, a novel overlapping gene in SARS-CoV-2, showing its presence in pangolin-CoVs and its evolutionary significance.

Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse

The study characterizes the Titan mouse as a model for metabolically unhealthy obesity and shows that dietary intervention improves its health and extends lifespan.

Salmonella Enteritidis Effector AvrA suppresses autophagy by reducing Beclin-1 protein

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

Infectious bronchitis virus attaches to lipid rafts and enters cells via clathrin mediated endocytosis

This study identifies the molecular mechanisms of infectious bronchitis virus (IBV) entry, showing it attaches to lipid rafts and enters via clathrin-mediated endocytosis, followed by endosomal trafficking and membrane fusion.

CHOP and IRE1α-XBP1/JNK signaling promote Newcastle Disease Virus induced apoptosis and benefit virus proliferation

This study identifies CHOP and IRE1α-XBP1/JNK signaling as mediators of NDV-induced apoptosis and their role in promoting virus proliferation in tumor cells.