CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal LRR motif for binding interaction partners
A. Stadler, H. B. Gabriel, L. V. De Liz, S. Alonso-Gil, X. Deng, R. Crickley, K. Korbula, K. Huang, B. Zagrovic, S. Vaughan, J. Sunter, G. Dong
This study reports the crystal structure of the N-terminal domain of CFAP410 and shows how mutations in this domain disrupt its structural stability and interaction with partners, leading to disease.
bioRxiv · Sep 21, 2022 · PreprintBiochemistry