X. Deng

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

This study identifies phosphoglycerate mutase (PGAM) as a regulator of Treg differentiation through serine synthesis and one-carbon metabolism, showing its impact on immune suppression and autoimmunity.

Ferroptosis regulates hemolysis in stored murine and human red blood cells

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

Higher functional resilience of temperate forests at intermediate latitudes of a large latitudinal gradient in South America

The paper assesses plant functional composition in temperate forests across a latitudinal gradient in South America, identifying key environmental drivers and highlighting regions with high functional resilience.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Why models underestimate West African tropical forest productivity

The paper investigates why models underestimate West African tropical forest productivity and finds that using local field measurements improves model accuracy.

DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae

This study profiles the DNA methylome of Pseudomonas syringae and shows its role in regulating virulence and metabolism through 6mA methylation.

TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis

This study shows TPPB, a new PKC modulator, reduces neuroinflammation and promotes CNS repair in experimental MS by targeting innate immune cells.

Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

The paper maps the transcriptional regulatory network of Pseudomonas syringae, identifying hierarchical TF organization and functional roles in virulence and metabolism.

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restriction

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

Insights into B Cell and Antibody Kinetics Against SARS-CoV-2 Variants Using Mathematical Modelling

This study uses mathematical modeling to analyze B cell and antibody dynamics against SARS-CoV-2 variants, showing reduced neutralization against Omicron and enhanced secondary response.

Nanomechanics of wild-type and mutant dimers of the tip-link protein protocadherin 15

This study examines the nanomechanics of wild-type and V507D mutant PCDH15 dimers, showing that Ca2+ affects their stiffness and unfolding behavior, with implications for hearing.

Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein

The paper identifies SERF2 as a protein involved in stress granule formation and characterizes its interactions with G-quadruplex RNA structures to study liquid-liquid phase transitions.

Effects of protein G-quadruplex interactions on phase transitions and protein aggregation

This study shows Znf706 promotes protein aggregation but binds G-quadruplexes, which suppresses aggregation and affects mRNA levels.

Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1

This study compares the neutralization evasion of SARS-CoV-2 variants BA.2.86, XBB sublineages, and CH.1.1, finding BA.2.86 less evasive than XBB sublineages but CH.1.1 most evasive.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

Molossus molossus bats encompass at least two distinct genera of totivirus-like

This study identifies totivirus-like viruses in Molossus molossus bats, revealing two distinct phylogenetic clades with low similarity to known totiviruses.

Contrasting carbon cycle along tropical forest aridity gradients in W Africa and Amazonia

This study compares carbon cycle metrics across tropical forests in West Africa and Amazonia, finding higher productivity and lower efficiency in West African forests.

The Arabidopsis BUB1/MAD3 family protein BMF3 requires BUB3.3 to recruit CDC20 to kinetochores in spindle assembly checkpoint signaling

This paper identifies BUB3.3's role in recruiting CDC20 to unattached kinetochores via interaction with BMF3 in Arabidopsis, revealing a unique SAC mechanism distinct from fungi and animals.

Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment

This study identifies a subpopulation of Ewing sarcoma cells with CAF-like properties that remodel the tumor microenvironment through ECM deposition.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal LRR motif for binding interaction partners

This study reports the crystal structure of the N-terminal domain of CFAP410 and shows how mutations in this domain disrupt its structural stability and interaction with partners, leading to disease.

Glioma-BioDP: Database for Visualization of Molecular Profiles to Improve Prognosis of Brain Cancer

Glioma-BioDP provides a web tool for exploring RNA and protein expression profiles in low- and high-grade gliomas to aid in prognosis and treatment personalization.

Subtyping evaluation of Salmonella Enteritidis using SNP and core genome MLST with nanopore reads

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

Novel MBLs inhibitors screened from FDA-approved drug library restore the susceptibility of carbapenems to NDM-1-harbouring bacteria

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

Regulation of the PKD2 channel function by TACAN

This study identifies TACAN as a PKD2 inhibitor that modulates its channel activity and mechano sensitivity in renal cells and zebrafish.

Salmonella enterica serovar Typhimurium from Wild Birds in the United States Represent Distinct Lineages Defined by Bird Type

This study sequenced S. Typhimurium strains from wild birds in the U.S. and identified three distinct lineages associated with different bird types, improving source attribution and outbreak investigation.

The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants