J. Sunter

The C-terminus of CFAP410 forms a tetrameric helical bundle that is essential for its localization to the basal body

This study determines the structure of CFAP410's C-terminal domain and shows that its tetrameric helical bundle is essential for basal body localization, explaining how the L224P mutation causes ciliopathies.

3D electron microscopy of the Leishmania mexicana cell cycle: Patterns of organelle duplication and segregation and their implications for parasite biology

This study uses 3D electron microscopy to analyze Leishmania mexicana cell cycle stages, revealing organelle duplication, segregation patterns, and metabolic adaptations in different environments.

Discovery of essential kinetoplastid-insect adhesion proteins and their function in Leishmania-sand fly interactions

The paper identifies kinetoplastid-insect adhesion proteins (KIAPs) involved in Leishmania-sand fly interactions and shows their role in adhesion and colonization.

Identification of 30 transition fibre proteins reveals a complex and dynamic structure with essential roles in ciliogenesis

The paper identifies 30 new transition fibre proteins in Trypanosoma brucei and shows their dynamic roles in ciliogenesis and flagellum length regulation.

Unlocking Trypanosome Biology: A Comprehensive Protein-Tagging Toolkit for Localization and Functional Analysis

The paper expands a protein-tagging toolkit for trypanosomes with over 100 vectors, enabling flexible localization and functional analysis of proteins using diverse fluorescent and biochemical tags.

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal LRR motif for binding interaction partners

This study reports the crystal structure of the N-terminal domain of CFAP410 and shows how mutations in this domain disrupt its structural stability and interaction with partners, leading to disease.

Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activator

The paper identifies ESB1 as a stage-specific activator required for monoallelic VSG transcription in Trypanosoma brucei, revealing its role in Pol I recruitment to the expression site body.

Role for the flagellum attachment zone in the resolution of cell membrane morphogenesis during Leishmania cell division

This study investigates the role of FAZ2 in Leishmania cell division, showing that its loss disrupts membrane organization and reduces parasite viability in sand flies and mice.

A key regulatory protein for flagellum length control in stable flagella

This paper identifies Cep164C as a key protein involved in maintaining stable flagellum length in Trypanosoma brucei by acting as a molecular lock at the flagellum base.