A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis
Y. GUAN, A. Enejder, M. Wang, Z. Fang, L. Cui, S.-Y. Chen, J. Wang, Y. Tan, M. Wu, X. Chen, P. K. Johansson, I. Osman, K. Kunimoto, P. Russo, S. C. Heilshorn, G. Peltz
This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.
Nature Communications · Oct 22, 2021Peer-reviewedCell Biology