Z. Fang

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

This paper identifies a novel penetration ring formed by secreted proteins in the rice blast fungus after cell wall penetration, which persists at the plasma membrane interface during invasion.

Structural insights into the in situ assembly of clustered protocadherin γB4

This study investigates the in situ assembly of cPcdh-γB4 using electron tomography, revealing distinct roles of ectodomain and intracellular domain in intermembrane organization.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

Identification of a Conserved B-Cell Epitope on the Capsid Protein of Porcine Circovirus Type 4

This study identifies a conserved B-cell epitope on the PCV4 capsid protein, which could aid in vaccine and detection strategies for PCV4.

Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

The paper introduces MEMORY, a method to identify GEARs associated with cancer prognosis, finding mitosis-related genes in LUAD and immunity-related genes in BRCA.

Diaminopurine in Nonenzymatic RNA Template Copying

This study investigates whether replacing adenine with diaminopurine in nonenzymatic RNA template copying improves efficiency and reduces bias.

ATP13A1 engages GET3 to facilitate substrate-specific translocation

The paper shows ATP13A1 uses GET3 to translocate cleaved signal sequences to the ER in a substrate-specific manner, ensuring efficient and accurate protein localization.

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

Single-cell RNA sequencing of peripheral blood mononuclear cells reveals complex cellular signalling signatures of metformin treatment type 2 diabetes mellitus

This study uses single-cell RNA sequencing to analyze immune cell signaling in T2DM patients on metformin, identifying key gene correlations and pathways involved in disease mechanisms.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

One-pot virus detection based on isothermal amplificationcoupled with temperature-activated argonaute

This paper develops a one-step virus detection method using immobilized thermotolerant Ago to separate amplification and cleavage steps, achieving high sensitivity and specificity.

Anti-adipogenic properties of clock activator chlorhexidine and a new derivative

This study identifies chlorhexidine and its derivative CM002 as clock activators with anti-adipogenic properties, showing they inhibit adipogenesis via Wnt pathway activation.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Integrated Organ Immunity: Antigen-specific CD4-T cell-derived IFN-γ induced by BCG imprints prolonged lung innate resistance against respiratory viruses

A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules

This paper synthesizes seleno-modified DNA oligonucleotides and shows they resist nuclease digestion while maintaining RNase H activity.

Complement C3 reduces apoptosis in human cardiomyocytes

This study shows exogenous Complement C3 reduces apoptosis in human cardiomyocytes by interacting with the intrinsic apoptotic pathway.

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

Hem25p is a mitochondrial IPP transporter

The paper identifies Hem25p as a mitochondrial IPP transporter in yeast, essential for CoQ biosynthesis.

Analysis of the SARS-CoV-2 spike protein revealed that blocked receptor-binding domain antigenicity decreases the production of neutralizing antibodies in vivo

This study shows that ACE2 binding blocks RBD antigenicity, reducing neutralizing antibody production, and suggests improving vaccine efficacy by exposing RBD immunogenicity.

Polyvalent mRNA vaccination elicited potent immune response to monkeypox surface antigens

This study develops a polyvalent mRNA vaccine against monkeypox virus and shows it elicits strong antibody responses to key surface antigens in animal models.

Isolation and characterization of a novel phage of Vibrio parahaemolyticus with biocontrol potential

The paper isolates and characterizes a novel lytic vibriophage, R16F, which shows potential as a biocontrol agent against V. parahaemolyticus due to its specificity and lack of virulence factors.

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Comprehensively characterizing evolutionarily conserved differential dosage compensations of the X chromosome during development and in diseases

The paper identifies two X gene groups with distinct dosage compensations during development and in diseases, and discovers new regulators of X dosage compensation.

Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron subvariants BA.2, BA.2.12.1 and BA.5

This study evaluates bivalent mRNA vaccine boosters against Omicron subvariants, showing that Delta & BA.2 bivalent boosters provide better neutralizing antibody titers than monovalent ones against BA.4/5.

Development and application of an uncapped mRNA platform

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.