Author

K. Leng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:E. coli· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

C. D. Kinz-Thompson· 2 shared J. E. Ramos· 2 shared J. F. Hunt· 2 shared J. Kim· 2 shared L. Zhu· 2 shared N. K. Karpowich· 2 shared R. L. Gonzalez· 2 shared A. W. Kao· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

C. D. Kinz-Thompson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer

L. Zhu, J. Kim, K. Leng, J. E. Ramos, C. D. Kinz-Thompson, N. K. Karpowich, R. L. Gonzalez, J. F. Hunt

The paper investigates the interaction kinetics of the SBP with a type II ABC importer using FRET, revealing a locked complex formation that requires ATP hydrolysis and is inhibited by ATP or B12 binding.

bioRxiv · Dec 2, 2022 · PreprintBiophysics

Realtime observation of ATP-driven single B12 molecule translocationthrough BtuCD-F

L. Zhu, J. Kim, K. Leng, J. E. Ramos, C. D. Kinz-Thompson, N. K. Karpowich, R. L. Gonzalez, J. F. Hunt

This study uses smFRET to observe real-time ATP-driven translocation of B12 through the E. coli BtuCD-F transporter, revealing two sequential conformational changes.

bioRxiv · Dec 2, 2022 · PreprintBiophysics

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

K. Leng, B. Rooney, F. McCarthy, W. Xia, I. V. L. Rose, S. Bax, M. Y. Chin, S. Fathi, K. A. Herrington, M. Leonetti, A. W. Kao, S. P. J. Fancy, J. E. Elias, M. Kampmann

bioRxiv · Sep 11, 2021 · PreprintCell Biology