C. D. Kinz-Thompson

This paper introduces tMAVEN, a software platform for analyzing single-molecule data using multiple kinetic models to improve accuracy by addressing mismatches between models and molecular mechanisms.

This study uses single-molecule fluorescence imaging to investigate how eIF4F recognizes and activates mRNA caps, revealing allosteric communication and subunit functions in the process.

This paper introduces a new resolution metric for structural biology that quantifies how effectively biomolecular structural information is captured across different length scales.

The paper investigates the interaction kinetics of the SBP with a type II ABC importer using FRET, revealing a locked complex formation that requires ATP hydrolysis and is inhibited by ATP or B12 binding.

This study uses smFRET to observe real-time ATP-driven translocation of B12 through the E. coli BtuCD-F transporter, revealing two sequential conformational changes.

This study reveals how ligands modulate the free energy landscape of the bacterial ribosome by altering its structural flexibility, suggesting entropic control as a general mechanism for regulating biomolecular machines.

This study uses single-molecule experiments to show that VcINDY, a sodium-coupled dicarboxylate transporter, uses stochastic elevator-like motions for substrate translocation, with non-cooperative protomer movements and cooperative binding.

The paper explains how Bayesian inference provides a comprehensive framework for analyzing single-molecule experiments by rigorously accounting for uncertainties and integrating multiple experiments.

This paper introduces a Bayesian inference method to enhance time resolution in single-molecule experiments by inferring faster dynamics than the experimental technique can capture.