Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1
D. R. Richardson, J. Paluncic, M. Gholam Azad, D. Lanbe, J. Skoda, K. Park, S. Chiang, D.-H. Bae, R. Scolyer, R. Afroz, G. Babu, J. Wilmott, K. Loh, P. Jansson, M. Dharmasivam, , Z. Kovacevic
This study identifies MTf as a pro-oncogenic WNT agonist that forms a bidirectional feedback loop with NDRG1, promoting melanoma progression and metastasis.
bioRxiv · Feb 27, 2023 · PreprintCancer Biology