Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes
C.-H. Yang, D. Ann-Onda, X. Lin, S. Fynch, S. Nadarajah, E. Pappas, X. Liu, J. Scott, J. S. Oakhill, S. Galic, Y. Shi, A. Moreno-Asso, C. Smith, T. Loudovaris, I. Levinger, , K. Loh
This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.
bioRxiv · May 14, 2021 · PreprintCell Biology