Author

K. Lythgoe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 3

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Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:virus· 1

Frequent Co-Authors

J. Raghwani· 2 shared A. G. Lopez· 1 shared A. Jaberi· 1 shared A. K. Chemel· 1 shared A. Le· 1 shared A. Lopez· 1 shared A. Pradhananga· 1 shared A. R. Mahoney· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersEvolutionary Biology

J. Raghwani

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3 papers

Recent·Most cited

Limited evolution despite years of measurable viremia in a cART-treated seronegative HIV-1 positive individual

H. R. Fryer, J. Raghwani, M. J. Gill, G. van Marle, T. Golubchi, J. Grove, K. Lythgoe

The paper analyzes viral evolution in an HIV-1 infected individual on cART who lacked detectable antibodies, finding limited viral evolution despite prolonged viremia.

bioRxiv · Feb 20, 2020 · PreprintEvolutionary Biology

A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection

C. Illingworth, J. Raghwani, D. Serwadda, N. K. Sewankambo, M. Robb, M. Eller, A. Redd, T. Quinn, K. Lythgoe

This study uses a novel multi-locus method to infer selection effects on HIV-1 variants in untreated patients, finding a broad distribution of beneficial fitness effects with many variants under weak selection.

bioRxiv · Nov 6, 2019Evolutionary Biology

CpG-creating Mutations are Costly in Many Human Viruses

V. R. Caudill, S. Qin, R. Winstead, J. Kaur, K. Tisthammer, E. G. Pineda, O. Carja, R. M. Eggo., K. Koelle, K. Lythgoe, S. Roy, N. Allen, M. Aviles, B. A. Baker, W. Bauer, , Wint

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.

bioRxiv · Jul 25, 2019Evolutionary Biology