S. Qin

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Calculating Structure Factors of Protein Solutions by Atomistic Modeling of Protein-Protein Interactions

The paper introduces FMAPS(q), a method to calculate protein solution structure factors using atomistic modeling of protein-protein interactions, showing agreement with experimental scattering data.

Scaling laws of molecular residence time

The paper reveals power law residence scaling in both passive and active liquids, showing sensitivity to liquid environment and suggesting active phase separation as a scaling proofreading mechanism in gene regulation.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

Structural framework for the understanding spectroscopic and functional signatures of the cyanobacterial Orange Carotenoid Protein families

The paper presents the first crystal structures of OCP2 from different cyanobacteria and compares them with OCP1 and OCP3 to correlate structural features with spectroscopic and functional properties.

Atomistic Modeling of Liquid-Liquid Phase Equilibrium Explains Dependence of Critical Temperature on γ-Crystallin Sequence

The paper uses atomistic modeling to show that a single amino-acid substitution in γ-crystallin affects liquid-liquid phase equilibrium and critical temperature.

Redundant and distinct roles of two 14-3-3 proteins in Fusarium sacchari, pathogen of sugarcane Pokkah boeng disease

This study investigates the roles of two 14-3-3 proteins in Fusarium sacchari, showing redundancy and distinct functions in pathogenicity and development.

Bioorthogonal photocatalytic quinone methide decaging for cell-cell interaction labeling

The paper introduces a method to label and profile cell-cell interactions with high sensitivity and spatial-temporal resolution using a bioorthogonal photocatalytic quinone methide decaging strategy.

ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

Surf4 deficiency reduces intestinal lipid absorption and secretion and decreases metabolism in mice

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins

This paper introduces SeqDYN, a sequence-based method to predict residue-specific backbone dynamics of IDPs, identifying key amino acids involved in slow dynamics.

Plant selection and ecological microhabitat drive domestications of shrub-associated microbiomes in a revegetated shrub ecosystem

This study examines how plant selection and ecological microhabitats influence the microbiomes of revegetated shrubs, finding that microhabitats, not plant species, primarily drive microbial community composition.

Phase separation as high-order catalyst

The paper proposes a model where phase separation of regulatory elements acts as a catalyst for chromatin-mediated reactions by lowering activation barriers and stabilizing transition states.

Comparative genomic analyses of Lactococcus garvieae isolated from bovine mastitis in China

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

A genetic model for in vivo proximity labeling of the mammalian secretome

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

A small-molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

Preferential interactions of a crowder protein with the specific binding site of a native protein complex

This paper investigates how crowder proteins affect the binding affinity and kinetics of the EIN-HPr protein complex using NMR and atomistic modeling, revealing preferential interactions that destabilize the complex.

Cell-to-cell variability in inducible Caspase9-mediated cell death

The paper investigates cell-to-cell variability in iCasp9-mediated cell death and identifies initial iCasp9 expression and XIAP/Caspase3 ratio as key factors, showing that combinatorial drugging can reduce drug resistance.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

Weight loss response following lifestyle intervention associated with baseline gut metagenomic signature in humans

The paper analyzes weight loss outcomes in response to a lifestyle intervention and identifies baseline gut metagenomic features associated with weight loss in humans.

Convergent evolution of distinct immune sensor systems for fungal polygalacturonases in Brassicaceae

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

This study finds adolescents cooperate less than adults in social dilemmas due to lower intrinsic reward for reciprocity, not poor expectation of others' cooperation.

An ABA Synthesis Enzyme Allele OsNCED2 Promotes the Aerobic Adaption in Upland Rice

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.

Soil bacterial biomass and diversity are affected by different furrow-ridge mulched management systems during potato continuous cropping

This study examines how different furrow-ridge mulched management systems affect soil bacterial biomass and diversity in continuous potato cropping, finding that full mulch on ridges enhances soil properties and microbial diversity.