Author

K. M. Alden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. J. Krysan· 2 shared S. R. Beattie· 2 shared A. J. Jezewski· 1 shared D. Fox· 1 shared M. C. Montoya· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

D. J. Krysan

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MicrobiologybioRxivMar 16, 2022

Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection

K. M. Alden, A. J. Jezewski, S. R. Beattie…·D. J. Krysan

This study identifies multiple acetyl-CoA-generating pathways in Cryptococcus neoformans essential for infection, showing synthetic lethality between ACL1 and ACS1 and reduced fitness in vivo.

DOI 10.1128/mbio.01279-22

fungi (other)genetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivNov 22, 2019

Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates

M. C. Montoya, S. R. Beattie, K. M. Alden, D. J. Krysan

This study identifies mefloquine derivatives as broad-spectrum antifungals effective against drug-resistant fungal isolates, with mechanisms involving mitochondrial and vacuolar disruption.

DOI 10.1128/aac.02331-19

experimental assayhost-pathogen & immune response

𝕏 PostBluesky