MicrobiologybioRxivPreprint
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms
DOI 10.1101/2023.05.01.538946
Author
S. R. Beattie
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagApproach:experimental assay· 7Research Focus:host-pathogen & immune response· 5Research Focus:drug response / drug discovery· 3Organism:fungi (other)· 3Organism:C. elegans· 2Research Focus:cell type annotation· 2Research Focus:gene regulatory network inference· 2Approach:genetic perturbation / CRISPR· 2
Activity by Year
2018-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 11 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship8 papers
Recent·Most cited
- MicrobiologybioRxivPreprint
Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo Candida albicans vascular catheter infection and ex vivo Candida auris skin colonization
S. R. Beattie, T. Esan, R. Zaronowaki…·D. J. Krysan
This study identifies and characterizes novel keto-alkyl-pyridinium antifungal molecules with broad spectrum activity against fungi, showing efficacy in in vivo and ex vivo models of infection.
- MicrobiologybioRxiv
FKS1 is required for Cryptococcus neoformans fitness in vivo: application of copper-regulated gene expression to mouse models of cryptococcosis
S. R. Beattie, A. Jezewski, L. C. Ristow…·D. J. Krysan
This paper uses copper-regulated gene expression to study FKS1 in C. neoformans, showing reduced in vivo fungal burden with lower FKS1 expression.
DOI 10.1128/msphere.00163-22 - MicrobiologybioRxiv
Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection
K. M. Alden, A. J. Jezewski, S. R. Beattie…·D. J. Krysan
This study identifies multiple acetyl-CoA-generating pathways in Cryptococcus neoformans essential for infection, showing synthetic lethality between ACL1 and ACS1 and reduced fitness in vivo.
DOI 10.1128/mbio.01279-22 - MicrobiologybioRxivPreprint
An Alanine Aminotransferase is Required for Polysaccharide Regulation and Resistance of Aspergillus fumigatus Biofilms to Echinocandin Treatment
J. D. Kerkaert, F. Le Mauff, B. R. Wucher…·R. A. Cramer
This study shows that alanine aminotransferase AlaA is essential for A. fumigatus biofilm formation and resistance to echinocandin antifungals, with its inhibition increasing drug susceptibility.
DOI 10.1101/2021.06.03.446912 - MicrobiologybioRxiv
Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates
M. C. Montoya, S. R. Beattie, K. M. Alden, D. J. Krysan
This study identifies mefloquine derivatives as broad-spectrum antifungals effective against drug-resistant fungal isolates, with mechanisms involving mitochondrial and vacuolar disruption.
DOI 10.1128/aac.02331-19 - MicrobiologymBioPeer-reviewed
Host carbon dioxide concentration is an independent stress for Cryptococcus neoformans that affects virulence and antifungal susceptibility
D. J. Krysan, B. Zhai, S. R. Beattie…·X. Lin
This study identifies CO2 tolerance as a virulence trait in Cryptococcus neoformans, linking it to disease severity and antifungal drug susceptibility.
DOI 10.1128/mbio.01410-19 - MicrobiologybioRxiv
Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, a close relative of the major human fungal pathogen Aspergillus fumigatus
M. E. Mead, S. L. Knowles, H. A. Raja…·A. Rokas
This study compares Aspergillus fischeri and Aspergillus fumigatus to understand differences in pathogenicity, finding A. fischeri is less virulent, grows slower under stress, and has divergent secondary metabolism.
DOI 10.1128/msphere.00018-19