Author

K. M. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

L. Shan· 2 shared Q. Wang· 2 shared C. J. DeSelm· 1 shared G. H. Harlan· 1 shared H. Gao· 1 shared P. Tang· 1 shared R. M. Presti· 1 shared S. B. Kutluay· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

L. Shan

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 1, 2021

CARD8 inflammasome sensitization through DPP9 inhibition enhances NNRTI-triggered killing of HIV-1-infected cells

K. M. Clark, Q. Wang, L. Shan

The paper shows that inhibiting DPP9 with Val-boroPro enhances NNRTI-induced killing of HIV-1-infected cells by sensitizing the CARD8 inflammasome.

DOI 10.1101/2021.09.01.458624

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 25, 2020

CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activity

Q. Wang, H. Gao, K. M. Clark…·L. Shan

This study identifies CARD8 as a sensor of HIV-1 protease activity, triggering pyroptosis of infected cells and clearing latent HIV-1 in CD4+ T cells.

DOI 10.1101/2020.09.25.308734

humanexperimental assay

𝕏 PostBluesky