L. Shan

Modulation of stress granule dynamics by phosphorylation and ubiquitination in plants

This study identifies phosphorylation and ubiquitination as key regulators of TZF1 stress granule assembly in Arabidopsis.

PlexinD1 deficiency in CD11c+ dendritic cells exacerbates airway hyperresponsiveness and enhances IgE and mucus production in allergic asthma

The CARD8 inflammasome drives CD4+ T-cell depletion in HIV-1 infection

This study identifies the CARD8 inflammasome as a driver of CD4+ T-cell depletion in HIV-1 infection through non-productive viral sensing.

dsRNA-induced immunity targets plasmodesmata and is suppressed by viral movement proteins

This study shows dsRNA-induced immunity targets plasmodesmata by triggering callose deposition to restrict virus movement, which is suppressed by viral movement proteins.

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

Human neutrophil development and functionality are enabled in a humanized mouse model

This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Increase in nutrient availability promotes success of invasive plants through increasing growth and decreasing anti-herbivory defenses

This study shows that nutrient enrichment increases biomass and reduces anti-herbivory defenses in invasive plants, giving them a competitive advantage over native species.

CARD8 inflammasome sensitization through DPP9 inhibition enhances NNRTI-triggered killing of HIV-1-infected cells

The paper shows that inhibiting DPP9 with Val-boroPro enhances NNRTI-induced killing of HIV-1-infected cells by sensitizing the CARD8 inflammasome.

Immune elicitation by sensing the conserved signature from phytocytokines and microbes via the Arabidopsis MIK2 receptor

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activity

This study identifies CARD8 as a sensor of HIV-1 protease activity, triggering pyroptosis of infected cells and clearing latent HIV-1 in CD4+ T cells.

Ubiquitylome Analysis Reveals a Central Role for the Ubiquitin-Proteasome System in Plant Innate Immunity

The paper identifies ubiquitylated proteins in Arabidopsis during MAMP-triggered immunity, revealing the ubiquitin-proteasome system's role in immune regulation.

Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

Transcriptional Differences of Peanut (Arachis hypogaea L.) Seeds in the Fresh-harvest, After-ripened and Just-germinated States: insights into regulatory networks of seed dormancy-release and germination

This study identifies transcriptional changes in peanut seeds during dormancy release and germination, revealing key pathways and hormone-related genes involved in these processes.

ACPT gene is inactivated in mammalian lineages that lack enamel and teeth

The paper identifies ACPT gene inactivation in toothless and enamel-less mammals and estimates its inactivation times across different lineages.

Defining relative mutational difficulty to understand cancer formation and prevention

The paper introduces a method to predict the functionality of low-frequency missense mutations by integrating mutation counts with relative mutational difficulty, revealing functional p53 mutations and potential cancer prevention strategies.

Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Negatively Regulating Th17 Response

This study shows PTX3 suppresses Th17 responses and increases susceptibility to Leishmania major infection by inhibiting IL-17A production and Th17-specific transcription factors.