BiophysicsbioRxiv
Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain
P. T. Nguyen, H. M. Nguyen, K. M. Wagner…·V. Yarov-Yarovoy
The paper designs potent and selective peptide inhibitors of human NaV1.7 channels using Rosetta, with two peptides showing sub-nanomolar IC50 and high selectivity over other sodium channels.