Super elongation complex as a targetable dependency in diffuse midline glioma
N. A. Dahl, E. Danis, I. Balakrishnan, D. Wang, A. Pierce, F. Walker, A. Gilani, N. Serkova, K. Madhaven, S. Fosmire, A. Green, N. K. Foreman, S. Venkataraman, R. Vibhakar
This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.
bioRxiv · Jan 22, 2020Cancer Biology