Author

N. K. Foreman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

R. Vibhakar· 3 shared S. Venkataraman· 3 shared A. M. Donson· 2 shared A. Pierce· 2 shared B. Sanford· 2 shared D. Wang· 2 shared E. Danis· 2 shared I. Balakrishnan· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

R. Vibhakar

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Author profile →

4 papers

Recent·Most cited

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

F. M. Walker, L. Martin Sobral, E. Danis, B. Sanford, I. Balakrishnan, D. Wang, A. Pierce, S. D. Karam, N. J. Serkova, N. K. Foreman, S. Venkataraman, R. Dowell, R. Vibhakar, N. A. Dahl

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology

Neoplastic and Immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.

K. A. Riemondy, S. Venkataraman, N. Willard, A. Nellan, B. Sanford, A. M. Griesinger, V. Amani, S. Mitra, T. C. Hankinson, M. H. Handler, M. Sill, J. Ocasio, S. J. Weir, D. S. Malawsky, T. R. Gershon, , R. Vibhakar

The paper uses single-cell transcriptomics to identify subgroup-specific neoplastic and immune cell heterogeneity in childhood medulloblastoma.

bioRxiv · Aug 28, 2020Cancer Biology

Super elongation complex as a targetable dependency in diffuse midline glioma

N. A. Dahl, E. Danis, I. Balakrishnan, D. Wang, A. Pierce, F. Walker, A. Gilani, N. Serkova, K. Madhaven, S. Fosmire, A. Green, N. K. Foreman, S. Venkataraman, R. Vibhakar

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

bioRxiv · Jan 22, 2020Cancer Biology