An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
C. R. Fraire, K. Desai, U. A. Obalapuram, L. K. Mendyka, V. Rajaram, T. Sebastian, Y. Wang, K. Onel, J. Lee, S. X. Skapek, K. S. Chen
This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.
bioRxiv · Apr 23, 2024Cancer Biology