V. Rajaram

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation

This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.