S. Richard

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires, potentially mediated by DNA triplexes

This paper identifies a novel mechanism of antigenic variation in Pneumocystis jirovecii involving DNA triplex-mediated recombination of subtelomeric genes.

Opposing Strain Directions on Adjacent Left Ventricular Segments Predict Fibrotic Remodeling after Acute Myocardial Infarction

This study shows that opposing strain directions on adjacent left ventricular segments predict fibrotic remodeling after myocardial infarction, linking mechanical cues to transcriptional programs.

The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice

This study shows that Meis2 gene inactivation in mouse peripheral sensory neurons impairs cardiac baroreflex regulation, linking ASD-related sensory neuron dysfunction to cardiovascular autonomic imbalance.

Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart

This study identifies a late postnatal developmental stage in rodents where cardiomyocyte surface crests mature, regulating diastolic function through ephrin-B1-dependent mechanisms.

PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

This study shows PRMT7 inhibition enhances anti-tumor immunity and improves response to immune checkpoint blockade in melanoma by modulating immune cell infiltration and PD-L1 expression.

Patient Similarity Network of Multiple Myeloma Identifies Patient Sub-groups with Distinct Genetic and Clinical Features

The paper introduces MM-PSN, a multi-omics patient similarity network for Multiple Myeloma, identifying three broad groups and twelve sub-groups with distinct genetic and clinical features.

Long term outcomes of Everolimus therapy in de novo liver transplantation: a systematic review and meta-analysis of randomized controlled trials

This study evaluates the long-term outcomes of Everolimus therapy in liver transplant patients, finding improved renal function with non-inferior efficacy compared to standard calcineurin inhibitor therapy.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

iPSC-derived Cancer Organoids Recapitulate Genomic and Phenotypic Alterations of c-met-mutated Hereditary Kidney Cancer

The paper generates c-met-mutated iPSC-derived kidney organoids that recapitulate genomic and phenotypic features of PRCC, identifying common genes and validating their expression in both organoids and patient tumors.

Site-directed mutagenesis of the 1,3-β glucan synthase catalytic subunit of Pneumocystis jirovecii and susceptibility assays suggest its sensitivity to caspofungin

This study assesses caspofungin sensitivity of Gsc1 enzymes from Pneumocystis species using site-directed mutagenesis and functional complementation, finding similar sensitivity across species.

Mechanisms of surface antigenic variation in the human pathogenic fungus Pneumocystis jirovecii

This study identifies mechanisms of surface antigenic variation in Pneumocystis jirovecii using long-read sequencing and PCR, revealing gene family diversification and telomere-linked recombination.